Harding’s disease: an important MS mimic

Psychiatric onset Alexander disease: an important challenge in neuropsychiatric diagnosis

Introduction: Alexander disease is a heterogenous group of diseases with various manifestations based on age of disease onset. This rare leukodystrophy syndrome with mutations in GFAP Gene could present with developmental delay and seizure in infantile form to ataxia and bulbar palsy in adulthood. However psychiatric symptoms are not well-defined and usually evaluate after disease diagnosis not...

Spontaneous Spinal Epidural Hematoma as a Potentially Important Stroke Mimic

Hemiparesis develops in response to a wide range of neurological disorders, such as stroke, neoplasms and several inflammatory processes. Occasionally, it may also occur due to a lesion located in the high cervical spinal cord. In this concise review, we describe the features of spontaneous spinal epidural hematoma, which should be included in the large list of stroke mimics. Various concerns r...

An Important Differential: Extramammary Paget's Disease

Overlapping MS/MS spectra and disease proteomics

The ongoing success of the proteomics endeavor is the result of a prolific symbiosis between experimental ingenuity [2, 3, 4] and efficient bioinformatics [5, 6, 7, 8, 9, 10, 11]. Without these, ground-breaking landmarks such as the human genome project [12, 13] or the HUPO initiative [14] would likely not have seen the light of day. But despite valuable contributions, the road to a better unde...

Erdheim-Chester Disease as a Mimic of IgG4-Related Disease

Immunoglobulin-G4 (IgG4)-related disease (IgG4RD) is a fibro-inflammatory disorder characterized by tissue-infiltrating IgG4 plasma cells, and, often, high serum IgG4. Several autoimmune, infectious, or proliferative conditions mimic IgG4RD. Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis, characterized by foamy histiocytic infiltration, fibrosis, and chronic inflammat...